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phenobarbital will lower the level or outcome of alfentanil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Unknown.phenobarbital will lessen the level or impact of diclofenac by affecting hepatic enzyme CYP2C9/ten metabolism. Insignificant/Importance Not known.phenobarbital will reduce the level or effect of isavuconaz